Assessing the safety and efficacy of fourthline antihypertensive agents to clinical practice Hypertension Medical Reviews Assessing the safety and efficacy of fourthline antihypertensive agents to clinical practice Watch Prof. Stéphane Laurent (France) discussing the article "Comparative Safety and Effectiveness of Aldosterone Antagonists Versus Beta-Blockers as Fourth Agents in Patients With Apparent Resistant Hypertension".